One thing I’ve noticed about Fantastic Beasts is that each of the main quartet is motivated by love, while the rest of the cast is motivated by fear or hatred.
Newt loves his animals and spends the movie trying to protect them. Tina seeks to do what is right and is driven to help those who are vulnerable, while Queenie loves people, especially her sister. And by opening a bakery, Jacob wants to be able to make other people happy doing something that he loves. When they are drawn into the movie’s conflict, it is in defense of the things they hold dear.
In contrast, President Seraphina Picquery is motivated by fear that the magical world will be exposed, Credence Barebone by fear of his own repressed powers, his mother Mary Lou by hatred of magic, and Grindelwald and his supporters by anger at the status quo and disdain for muggles. All three competing factions – MACUSA, Grindelwald, and Second Salem – define themselves by hatred and fear of each other.
While Newt and his friends are of course afraid in dangerous situations, they never allow their fear to control them. They certainly never give themselves over to hate. This contrast between the film’s four heroes and the world that surrounds them emphasizes the fact that in spite of their circumstances, they are constantly trying to do good and acting in defense of the things they love and value.